Poor performance in all games with high-end PC

SPUName with unicode symbols is normal.

If what I suggested so far doesn't work I have no other ideas.
Try live booting a Linux distro and testing it there to see what happens.

What would be the best distro to try?

If I may suggest ...
* How is the use of the Processor during the game? Low use or High use?

* If you use Windows 10, it usually keeps the core active so that Windows starts up faster, but this generates strange behavior after a few days, you can check the time in the Task Manager (CTRL + SHIFT + ESC) performance tab , CPU resource. If you have more than 5 days, RESTART the computer (it's not turning off and on, it's restarting).

* Does the emulator only perform poorly? Videos? Others games or Emulators?

* Are the drivers up to date?

* At Bios does the processor have an Overclock configuration or other customizations? Example CPU calibration

* Are you playing in full screen or window mode? 2 screens? What is the screen resolution and the resolution configured on the emulator?

* Did you try to temporarily disable the antivirus / sandbox?

* Its a 16C/32T CPU so core usage is hard to gauge, but here are some screenshots: https://imgur.com/a/WCT3jCm It seems that at least 5 threads do go up to 100% utilization, I don't know what the ideal should be.

* You can see on the screenshots the up time is low, I always make sure to fully shutdown every reboot.

* Everything else performs within spec of this PC, I linked to a recent Time Spy run with a decent score, all scores are within +-500pts from that.

* All drivers up to date

* All-core OC of 4500GHz with, using Asus Dark Hero with Dynamic OC switch which allows for PBO to still be enabled. This is moot however as I tested this with all values on optimized defaults (i.e. no OC or even PBO), as well as just PBO enabled and the results are all the same. Other applications (Time Spy, cinebench R20/R23, various game benchmarks) DO show the difference when switching from these various OC methods.

* Tried both full screen and windowed, same result. I do have 3 displays running at once, all 1920x1080. Emulator res is default 1280x720 with no scaling (see previous screenshots)

* I had NOT tried that, but I immediately did so after your suggestion. I did notice that in CPU-Z I could now see "AMD-V" instruction set listed under "Instructions" whereas with virtual machine platform/Sandbox enabled I could not see it. Sadly this had no effect whatsoever as you can see on the screenshots.

Quick update, I tried swapping CPU for an AMD 3800XT which is compatible with my motherboard. All other specs remain the same. I observed the EXACT same performance. Of course all other benchmarks did show the difference between CPUs (i.e. scaled lower scores across the board). I searched for rpcs3 benchmarks with this CPU or contemporary ones (not many available) and even those show significantly better performance. Now I have two distinct CPUs both show lower performance from what it is expected in this one application, so I am thinking the issue is another component. RAM? GPU? Are there reported issues with newer GPU architectures? using PCIe 3.0 vs 4.0? There has to be something else that rpcs3 does which other applications dont. As Ani suggested I will try live-booting to linux and test from there. Again thank you for all your help, and if you have any more leads I would really appreciate if you shared them.