Nier Audio and Visual Glitches

Sounds unrelated, af shouldn't hurt audio. Also never set anisotropic filtering to "force disable" it means that even the game cannot use it's own filtering. Audio issues usually stem from poor spu performance, trying interpreters is going to make it worse so there's no point trying that. Best thing to do would be to try defaults + spu llvm (if it works with the game) and change preferred spu threads to 1-3 see what's best. And with NieR make sure you have framelimiter set to 30, because RPCS3 isn't capping the framerate to 30 properly which is what the game is supposed to run at. And make sure you have write color buffers enabled.