Weird graphical issues with lighting after upscaling

Is anyone else experiencing issues with in-game lighting after upscaling? I notice that lights become extremely bright, have blocky textures appear around them, and look muddled when upscaling past the native resolution. Note that playing on a native resolution solves the issue, but playing games in 720p in pretty unbearable for me nowadays, so I'm hoping I can resolve this. Another thing to note is it seems to only affect games with complex lighting effects.