South Park: The Stick of Truth [BLUS31191]

RPCS3 Version: 0.0.21-13370-a4d715e2 Alpha

Was working great, default Vulkan settings (just res set to 200%) until just about to leave the house, the dad reprimands and orders you to leave and audio cuts out completely.

Anyone know how to fix that?

Maybe the SPU loop detection setting? That used to fix audio issues like this in a few games but to be honest I haven't checked it out in about a year or so, but that's what came to me off the top of my head.