Demon's Souls BLUS30443 Vulkan crash error

That error means Vulkan failed initialization - it's an issue on your system.
Try reinstalling your GPU drivers using DDU.

I had already tried reinstalling GPU drivers, with three different methods. I uninstalled through windows applications. That didn't work. Then I tried manually uninstalling and reinstalling. That didn't work, I uninstalled the drivers and rolled back to previous driver versions, twice with different versions to see if that would work. It didn't. I even downloaded Vulkan drivers and attempted to install them specifically, and I couldn't get that work either. I gave DDU a shot this morning because I hadn't used a driver cleaner to attempt a reinstall. That did not work, I'm still getting the error.

Today I finally tried another game that I know relies on Vulkan, and it failed to initialize my GPU drivers, so it's clear it IS the system drivers for my GPU. How to solve that issue is beyond me though.

Thanks for your advice, and I'm disappointed that it didn't work.

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Alright, so I got it to work.

I'm not sure exactly which step it was that fixed the issue, but here's what I did:

First I downloaded a driver version for my GPU that was 3-4 version older than the current driver, and I made a driver backup to make sure if something went wrong I had something I could roll back to.

Next I searched Change Device Installation settings in the windows search bar. This allowed me to turn off "automatically download manufacturers' apps" I believe this turns off Windows automatic installation of drivers (windows kept doing this on every restart despite the setting in DDU)

Then in Safe Mode I ran DDU, cleaning the drivers for a fresh install.

After reboot in to standard Windows, I verified through Device Manager: Display Adapters that it was the Windows Generic Display adapter. This can also be seen if your resolution doesn't change to your monitors highest resolution.

Then I made sure the Change Device Installation setting remained the same, and rebooted in to safe mode again.

In safe mode I searched my PC for every folder labeled Vulkan and NVIDIA, then deleted anything that was a shader cache or wasn't a part of game's NVIDIA logo. The earlier driver backup made this process a bit safer...

Finally after booting back in to standard Windows mode, I verified the Display Adapter was still the Windows Generic Display adapter. Then I installed the older driver I had downloaded earlier. I then tested some games that ran with Vulkan. RPCS3 did finally work.

If you have NVIDIA drivers, I highly recommend not updating to GeForce 456.55 Game Ready Driver until there's some semblance of stability.