Shadow of the Colossus [NPEA00280]

You can fix res scaling not working by enabling Force CPU Blit which can be found in the config.yml. But, you should only change it in a custom config specifically for SoTC. So, right-click the game, make the custom config, hit save, then right-click the game again and go to custom config folder and open the .yml file it selects and change "Force CPU Blit" from "FALSE" to "TRUE".

This same method works with some of the MLAA titles if you're using the patch, e.g Sly Cooper Thieves in Time. I think someone said it caused a graphical issue though, so i don't know..