PAIN (all 3 versions) suddenly broke after years of working fine

I've been playing the US version of PAIN for years, and it worked fine until today, when it now suddenly freezes after pressing play.  I made no changes to the settings or RPCS3 itself.  I've tried both of the European versions too (the HDD one, as well as dumping straight from my disk).  All 3 of them now freeze at the "Analyzing PPU Executable" screen (that very bizarre picture I've attached), with a lot of "E SIG: Thread.....is too sleepy" in the UI log at the bottom of the screen (I attached a pic of that here too).  RPCS3 itself then stops working, and I have to force close it through Windows task manager.  All of my other games still work perfectly fine.

Also, I tried rolling back RPCS3, and that didn't help either.  If anyone can help, please let me know.  I have no clue why only this one game (which of course is one of my absolute favorites) decided to stop working.