RPCS3 v0.0.5-6601-ee0fe28dd Alpha
Ingame, requires libaudio.sprx performance seems fine otherwise when this issue is fixed it may just be playable.
RPCS3 v0.0.22-13563-02d22dca Alpha
Playable, doesn't require libaudio anymore (and hasn't for at least 1-2 years).
I didn't finish the game, but I played for ~4 hours skipping through dialogue to test as much as possible quickly.
Everything i tested worked perfectly. The only tiny thing I noticed was that some of the plasma explosions dont render properly but it might be fixable with settings, I didn't try. See last screenshot.
Performance is great, i used vblank to let me get to the FPS cap of 58, and stay never dip below.
I don't have a ME2 save, but it would be good if someone tested importing one to see if it works.